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DRDO gets emergency use approval for oral anti-Covid drug

By TIOL News Service

NEW DELHI, MAY 08, 2021: AN anti-COVID-19 drug developed by the Institute of Nuclear Medicine and Allied Sciences (INMAS) of the Defence Research and Development Organisation (DRDO) in collaboration with Dr Reddy's Laboratories (DRL) has been granted emergency use approval by the drug regulators.

The Drugs Controller General of India (DCGI) has approved the therapeutic application of the drug 2-deoxy-D-glucose (2-DG) as adjunct therapy in moderate to severe COVID-19 patients.

Clinical trials showed the molecule helps in faster recovery of hospitalised patients and reduces supplemental oxygen dependence. Higher proportion of patients treated with 2-DG showed tested negative for Covid in RT-PCR tests.

The DRDO started lab testing 2-DG in April last year and found that the molecule worked effectively against the SARS-CoV-2 virus and inhibited viral growth. Based on these results, phase-2 trials were held from May-October and the drug was found to be safe in COVID-19 patients and showed significant improvement in their recovery. In efficacy trends, the patients treated with 2-DG showed faster symptomatic cure than Standard of Care (SoC) on various endpoints.

The phase-3 trials were conducted on 220 patients between December and March at 27 Covid hospitals. At least 42 per cent patients improved symptomatically and became free from supplemental oxygen dependence as compared to the 31 per cent in SoC, indicating an early relief from oxygen therapy. A similar trend was observed in patients over the age of 65.

Being a generic molecule and analogue of glucose, it can be easily produced and made available in plenty in the country. The drug comes in powder form in sachet, which is taken orally by dissolving it in water. It accumulates in the virus infected cells and prevents virus growth by stopping viral synthesis and energy production.


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